THE PREPARATION DESCRIPTION IS NOT INTENDED FOR MEDICATION WITHOUT PARTICIPATION OF THE DOCTOR!

What is it used for?
Used for treatment of the following diseases:
– lymphogranulomatosis (Hodgkin disease);
– some types of Non Hodgkin lymphomas;
– chronic lymphatic leukemia;
– Waldenstrom's macroglobulinemia;
– advanced ovarian adenocarcinoma;
– breast cancer (in some cases).

Contraindications and cautions:
- hypersensitivity to the active ingredient of the medication and to other alkylating agents;
- bone marrow hypoplasia (frank leucopenia, thrombocytopenia);
- epilepsy;
- renal insufficiency;
- severe compromised liver function;
- acute disease of gastrointestinal tract;
- previous treatment with other cytostatic drugs and radiation therapy;
- Pregnancy (especially in the 1st trimester).
- Breast-feeding should be stopped for the period of treatment.

Side effects:
- distress of bone marrow function (it is usually reversible if taking Leukeran cancelled on time);
- cough;
- shortbreathing;
- activation;
- confused mental state;
- hallucinations;
- tremor;
- painful urination;
- hematuria;
- hyperuricemia;
- aseptic cystitis;
- nephropathy;
- hydropses;
- azoospermia;
- menstrual disorders;
- supressed menstruation.

In rare cases:
- nausea;
- vomiting;
- diarrhea;
- sore mouth;
- gastrointestinal hemorrhage;
- skin rash;
- intense itching;
- urticaria fever;

In case of exceeding recommended therapeutic dosages there is a possibility of development of other side-effects.

Interactions:
- Leukeran increases the concentration of uric acid, which lowers the effect of antipodagric medicines, such as Allopurinol, Colchicine, Probenecid or Sulfinpyrazone, when treated from hyperuricemia and podagra (the dosages of antipodagric medicines should be corrected).

- Uricosuric agents increase the risk of nephropathy.

- Other myelotoxic medicines, radiation therapy may potentiate the development of myelodepression (neutropenia, thrombocytopenia).

- Leukeran is compatible with other cytostatic medications in combined chemotherapy (Methotrexate, Phthoruracilum) and also with Prednisolone

- If Leukeran is taken together with immunodepressants (glucocorticosteroids, azathioprine, corticotrophin, cyclophosphamide, cyclosporine, cytarabine, mercaptopurine) the risk of getting an infection and secondary tumors increases.

- If Leukeran is taken together with phenylbutazone there is a possibility that poisonous effect of Chlorambucil (and active ingredient of Leukeran) will be increased (the dosage might need to be reduced).

- Leukeran weakens the effectiveness of immunization by inactivated vaccines; When using living-virus vaccine Leukeran intensifies virus replication and side-effects of vaccination.