THE PREPARATION DESCRIPTION IS NOT INTENDED FOR MEDICATION WITHOUT PARTICIPATION OF THE DOCTOR!

What is it used for?
It is used to treat certain blood disorders such as chronic granulocytic leukaemia, polycythaemia vera and thrombocythaemia and myelofibrosis. It may also be used to prepare you for a procedure known as haematopoietic progenitor cell transplantation.

Contraindications and cautions:
Do not take Myleran if you have ever had an allergic reaction to busulphan or any of the ingredients listed at the end of this leaflet.
Symptoms of an allergic reaction may be mild or severe. They usually include some or all of the following: wheezing, swelling of the lips/mouth, difficulty in breathing, hayfever, lumpy rash ("hives") or fainting.
Unless your doctor says you should, do not take Myleran if you are pregnant, trying to become pregnant, breastfeeding or likely to father a child.
Myleran may harm the sperm, eggs and/or baby so reliable contraceptive methods MUST be taken to avoid pregnancy whilst you or your partner are taking these tablets.

Side effects:
Myleran works by reducing the number of new blood cells being made. Your doctor will do regular blood tests to check your blood cell levels. However, tell your doctor immediately if you notice any signs of fever or infection, or any unexpected bruising or bleeding, as this could mean that too few blood cells of a particular type are being produced.
Contact your doctor immediately if any of the following side effects occur:
The very common side effects of Myleran that have been reported in more than 1 in 10 people taking it include:
• reduction in number of white blood cells and platelets (which may affect clotting of blood)
• feeling sick, being sick, diarrhoea and mouth ulcers
• jaundice (yellowing of the whites of the eyes or skin)
• in women, periods may stop and fertility may be affected
• in girls, the onset of puberty may be delayed or prevented
• in boys and men, sperm production may be delayed, prevented, reduced or stopped.
Common side effects have been reported in between 1 in 10 and 1 in 100 people include:
• breathlessness due to heart not being able to beat properly, especially if you have thalassaemia
• pneumonia
• hair loss and appearance of patches of dark skin
• signs of blood in your urine and cystitis (pain when passing water)
• leukaemia.
Uncommon side effects reported in between 1 in 100 and 1 in 1,000 people taking Myleran include:
• in women, periods may stop and fertility may be affected
Rare side effects reported in between 1 in 1,000 and 1 in 10.000 people include:
• anaemia
• fits
• cateracts or other eye problems
• nausea, vomiting, diarrhoea and mouth ulcers
• jaundice (yellowing of the whites of the eyes or skin) and liver problems
• hair loss, dry mouth and lips or any changes to your skin for example excessive dryness, itching, rash or darker areas of skin pigmentation.
Very rare side effects reported in less than 1 in 10,000 people taking Myleran include:
• muscle weakness
• enlargement of breasts in male patients
• weakness, feeling tired, weight loss, feeling sick, being sick and dark skin patches.
If you are taking higher doses of Myleran the side effects may be worse. Ask your doctor for details.

Interactions:
Tell your doctor if you are taking any other medicines, including medicines you buy without a prescription from a pharmacy, supermarket or health food shop.
Some medicines may affect the way others work. Your doctor will be able to tell you what to do when taking Myleran with other medicines.