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Lopid

Product Information

What is Lopid?
The drug is indicated in patients with hyperlipoproteinemia types IIb, IV and V (when therapeutic diet, physical exercises and other lipid-lowering agents showed no effect), and secondary hyperlipoproteinemia conditioned by hard to treat diseases (diabetes, hypothyroidism, podagra).

What is the mechanism of action of Lopid?
The active ingredient of Lopid is gemfibrozil, a hypolipidemic agent which increases HDL (high density lipoprotein) cholesterol and decreases VLDL (very low density lipoprotein) cholesterol. Lopid increases the excretion of the free fatty acids from the liver and inhibits peripheral lipolysis, and thereby reduces triglycerides synthesis in the liver, decreases the inclusion of long-chain fatty acids into triglycerides which are newly synthesized, accelerates cholesterol circulation and its removal from the liver and increases its excretion by bile.

What is the proper dosage of Lopid?
The usual dosage of Lopid is 1200 mg taken in two divided doses about half an hour before the meal in the morning and in the evening. Please do not use Lopid without discussing this treatment mode with your healthcare provider.

What are the possible side effects of Lopid?
Lopid side effects are:
 - from the nervous system: headache, dizziness, extreme tiredness, paresthesia, depression, sleepiness, faintness;
 - from the digestive system: dry mouth, heartburn, loss of appetite, nausea, gastralgis, vomiting, stomach pain, diarrhea, flatulency, defecatory disability, hyperbilirubinemia, cholelithiasis, the increased activity of liver transaminases and alkaline phosphatase;
 - from the musculoskeletal system: arthralgia, myasthenia, rhabdomyolysis, myalgia;
 - from the hemopoietic system: anaemia, leucocytopenia, bone marrow hypoplasia;
 - from the urogenital system: reduced libido and/or sexual function;
 - allergic reactions: dermatitis, skin rash;
 - visual impairment, hypokaliemia, alopecia, synovitis.
If any Lopid adverse reactions occur please see your doctor.

Are there any contraindications?
Lopid is contraindicated in patients who are hypersensitive to gemfibrozil, have severe renal or hepatic dysfunction (including PBC (primary biliary cirrhosis)), or preexisting disease of gallbladder. Lopid therapy in combination with an HMG-CoA reductase inhibitor (statin family drug such as Fluvastatin, Lovastatin, Pravastatin, Rosuvastatin, Simvastatin, Atorvastatin) increases the risk of rhabdomyolysis. Do not take Lopid if you’re pregnant or nursing mother
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