Aciphex is an antiulcer medication, referred to the group of drugs, called proton pump inhibitors. The mechanism of action of this medication is achieved through the inhibition of the enzyme H-K-ATPase in gastric parietal cells, which leads to blockage of the final stage of formation of hydrochloric acid. This mechanism of action is completely dose-dependent and leads to inhibition of both basal and stimulated secretion of hydrochloric acid, regardless of the nature of the stimulus.
Aciphex is highly effective in the treatment of gastroesophageal reflux disease, pathological hypersecretion of hydrochloric acid, including Zollinger-Ellison syndrome, eradication of Helicobacter pylori in patients with peptic ulcer or chronic gastritis – in this case Aciphex works as a part of combination therapy with antibiotics. Clinical trials also showed high effectiveness of this medication in the treatment of stomach ulcer and duodenal ulcer in the acute stage as well as in the prevention of recurrence of peptic ulcer disease associated with Hp.
Patients who have hypersensitivity to any of Aciphex‘s components, must not administer this medication. Aciphex is as well contradicted for the usage in pregnant or breastfeeding women. People with severe hepatic impairment must use Aciphex with great caution. If Aciphex is taken in high dosages it is worth to keep in mind that the risk of hip, wrist and spine fractures drastically increases.
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