Adalat is an antianginal and antihypertensive medication. It has the ability to delay the entry of calcium ions into myocardial cells and smooth muscles of blood vessels on the "slow" channels of cell membranes. Under the influence of Adalat, coronary blood vessels dilate and the coronary blood flow considerably improves, decreasing the oxygen consumption in the myocardium. This medication also causes arterial vasodilation, which reduces total peripheral vascular resistance and lowers blood pressure.

Adalat has no inhibitory effect on the leading system of the heart. It reduces the concentration of quinidine in plasma and increases the concentration of digoxin in plasma. Therefore, the clinical effect and plasma digoxin should be carefully monitored. Patients, administrating Adalat should refrain from consuming of ethanol during the period of treatment.

Adalat is generally well tolerated, however, the relatively frequent side effects are the reddening of the face and skin of the upper body, headache.

Adalat must not be administered by people, suffering from severe forms of heart failure, unstable angina, acute myocardial infarction, sick sinus syndrome (heart disease, accompanied by arrhythmia), severe hypotension (low blood pressure). Administration of Adalat is contraindicated in pregnancy and breastfeeding. This medication must be administered with caution transport drivers and persons of other occupations that require rapid mental and physical reactions.

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