Allopurinol is an inhibitor of xanthine oxidase. Xanthine oxidase is the enzyme, which catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid, which in its turn is the end product of purine metabolism in human body.
Allopurinol inhibits the oxidation of endogenous purines of xanthine oxidase, which results in the decrease of concentration of uric acid and urine levels in serum, and the increase of the xanthine and hypoxanthine excretion with the urine. This medication lowers the lithates’ content in the blood and prevents their deposition in tissues and kidney. Allopurinol inhibits the formation of uric acid in the body, reduces concentrates uric acid salts in the blood and reduces the deposition of the cavities, tissues and urinary tract.
The above mentioned functions provide the high effectiveness of Allopurinol in the treatment of gout and hyperuricemia associated with tumors. The decrease in production of uric acid depends on the doses of Allopurinol.
Allopurinol is usually recommended for the treatment of such health conditions as gout, kidney stone disease with the formation of uric acid stones. It showed considerable results in treatment of diseases associated with the increased content of uric acid in the blood, such as certain types of leucosis, psoriasis, and treatment with high doses of corticosteroid drugs (cortisone, prednisolone and others). Allopurinol must be administered orally after the meal in the amount of 1-2 pills twice a day. As a rule, the course of treatment lasts for 2-4 weeks.
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