Ampril is a long-acting inhibitor of the angiotenztransforming enzyme, which has the increased affinity with the ATE tissue, which defines its strong organoprotective function. The effectiveness of Ampril, unlike the effect of the majority of other ATE inhibitors, is noticed not only in standard functions, common to all drugs of this group, but also in the prevention of cardiovascular complications in patients at high risk.

The mechanism of action of Ampril is rather complicated, it suppresses the synthesis of angiotensin II, reduces its vasoconstrictor action by narrowing the lumen of blood vessels as well as its stimulating effect on the secretion of aldosterone. This process leads to the increase in plasma renin activity. Ampril also inhibits the metabolism of bradykinin to prevent the degradation in the body. This medication reduces the total peripheral vascular resistance and does not significantly change the renal blood flow.
Ampril is widely recommended for the treatment of such health conditions as arterial hypertension, congestive heart failure, prevention of sudden death after myocardial infarction.

It must not be administered by persons who have hypersensitivity to any of the Ampril components, as well as by those who suffer from the narrowing of the aorta, hypertrophic cardiomyopathy, primary hyperaldosteronism, severe renal dysfunction and hepatic failure.

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