Capoten is a medication, referred to the group of drugs, called inhibitors of angiotensin-converting enzyme (ACE). Capoten suppresses the formation of angiotensin II and removes its vasoconstrictive effect on arterial and venous vessels. This medication as well reduces the total peripheral vascular resistance and blood pressure, as well as decreases the afterload. Capoten works by decreasing the preload and reducing the pressure in the right atrium and the pulmonary circulation, which eventually leads to the reduction of the release of aldosterone in the adrenal glands.

After the administration of Capoten, its main ingredient captopril is quickly absorbed. The bioavailability of the absorption reaches 60-70%. The administration of Capoten together with food slows the absorption of the drug by 30-40%.

In Europe and US Capoten is widely prescribed for the treatment of such conditions as hypertension, including renovascular one, chronic heart failure (as part of combination therapy), left ventricular dysfunction after myocardial infarction in clinically stable condition, diabetic nephropathy and diabetes mellitus type 1 (with albuminuria more than 30 mg / day). Prior to launching of the treatment with Capoten and during the entire course the renal function must be thoroughly monitored.

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