Cefazolin is a strong semi synthetic antibiotic, referred to the group of antibiotics, based on cephalosporin. Cefazolin is designed for parenteral use. Like all other beta-lactam antibiotics, Cefazolin has a bactericidal action, which is based on a prevention of the bacterial synthesis of cell membranes. Cefazolin can be called the "gold standard", as it is the least toxic first-generation cephalosporin antibiotic for parenteral administration.
Clinical trials have shown that Cefazolin is extremely efficient for the treatment of infectious diseases caused by susceptible to it Gram-positive and Gram-negative microorganisms, such as pneumonia, lung abscess, pleural empiemy, peritonitis, septicemia, endocarditis, osteomyelitis wound, burn infections, urinary tract infections, infections of skin and soft tissues, infections of osteoarticular apparatus.
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Cefazolin is administered intramuscularly and intravenously. Solutions for injections and infusions are prepared by dissolving solids in water or in 0.9% sodium chloride solution. For adequate dissolving of the solids it should be spend no less than 4 ml of solvent per gram of dry powder.
Dosage of Cefazolin depends on the age of the patients, disease and the severity of the disease. In treatment of uncomplicated diseases in adults Cefazolin is usually administered in the dosage of 500 mg to 1 gram two or three times a day. For moderately severe and severe infections, adults must receive the dosage of 500mg to 1g three or four times a day.
One must be very careful with the administration of this medication, as it can cause serious side effects, such as itching, allergic nephritis. People with kidney and liver diseases must consult a doctor prior to Cefazolin administration.
