Cozaar is a specific medication; it is the antagonist of angiotensin II (type AT1). Cozaar does not suppress exopeptidase - the enzyme that destroys bradykinin. This medication works by reducing the number of substances and processes in our body, such as PR, afterload, systemic blood pressure and pressure in the pulmonary circulation.
Cozaar show
ed high positive results in renoprotective action in patients with hypertension and diabetes mellitus complicated by nephropathy, during the international, placebo-controlled study. This research involved 1,513 persons from 28 countries and the research lasted 3.4 years. The research showed that Cozaar’s specific blockade of angiotensin II receptor in hypertensive patients with insulin-dependent diabetes mellitus (type II) and nephropathy helps to control the disease and decreases the development of end-stage renal disease.

Cozaar is commonly recommended for the treatment of arterial hypertension and heart failure in those cases where the use of ACE inhibitors is no longer suitable for the patient. Pregnant and breastfeeding women as well as those patients, who have the hypersensitivity to the drug or any of its components, must not administer Cozaar. Patients with impaired liver function should administer lower doses of Cozaar. There is no need for the correction of the initial dosage of Cozaar in elderly patients and patients with impaired renal function, including patients on dialysis. Cozaar can be administered with or without food. Side effects of this medication are rather rare, and include diarrhea, headache and itching.

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