Cymbalta is an antidepressant, serotonin reuptake inhibitor and norepinephrine, a medication for the treatment of depression and painful form of diabetic neuropathy. This medication works by inhibiting the reuptake of serotonin and noradrenalin, resulting in the increased serotonergic and noradrenergic neurotransmission in the central nervous system.

Cymbalta weakly inhibits dopamine capture, not having a significant effect for histaminergic, dopaminergic, cholinergic and adrenergic receptors. This medication has a central mechanism for the suppression of pain that is primarily manifested in higher pain threshold of pain of neuropathic etiology.

The active ingredient of Cymbalta is duloxetine. After the administration of Cymbalta, Duloxetine is quickly absorbed from the gastrointestinal tract. The absorption begins in 2 hours and the maximum concentration is achieved after 6 hours. The administration of Cymbalta with food reduces the extent of absorption by nearly 11%, which increases the time of reaching the maximum concentration of up to 10 hours.

This medication can be taken with or without food, orally, with a glass of water. Cymbalta is contradicted for patients with hypersensitivity to any of its ingredients. This medication must not be taken together with monoamine oxidase inhibitors (MAOIs). Patients, suffering from the uncorrected angle-closure glaucoma also must not take Cymbalta.

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