Glucotrol is a hypoglycemic medication, which possesses pancreatic and extra-pancreatic actions. Glucotrol works by stimulating the insulin secretion by lowering the threshold for glucose stimulation of beta cells in the pancreas. This process leads to the considerable increase in the insulin sensitivity and the degree of its binding to target cells. Glucotrol increases insulin release, enhances the effect of insulin on glucose uptake by muscles and liver and inhibits lipolysis in adipose tissue.
Efficiency of hypoglycemic effect directly depends on the number of functioning beta cells. Besides its primary function, Glucotrol has a lipid-lowering effect which is achieved when fibrinolytic action inhibits platelet aggregation. This medication as well performs a mild diuretic effect. Hypoglycemic action of Glucotrol becomes notable in 10-30 minutes after the administration.
Glucotrol is a perfect remedy for the treatment of type 2 diabetes if the diet and exercises proved to be ineffective. This medication is rather strong; therefore it is contraindicated to patients who suffer from diabetic ketoacidosis, diabetic precoma and coma, hyperosmolar coma, extensive burns, the big surgery, severe trauma and infectious diseases, diabetes mellitus type 1 as well as by those who have hypersensitivity to any of the drug’s components.
Pregnant and breastfeeding women must avoid using Glucotrol. This medication can be administered with great caution in patients who have leukopenia, diseases of the digestive tract, liver or renal failure, Febrile syndrome, intestinal obstruction, gastric paresis or diarrhea.
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