Isordil is a peripheral vasodilator with a predominant effect on the venous vessels. Isordil stimulates the formation of a "first pass" of nitric oxide, in other words, it performs the endothelial relaxing action in the vascular endothelium, causing activation of intracellular guanylate cyclase.

Isordil is widely prescribed as an antianginal agent in chronic coronary heart disease to prevent strokes, with infrequent attacks of stable angina. This medication is as well effective in the lowering of the tone of peripheral veins, as well as in reduction of venous blood flow to the heart, pressure in the vessels of pulmonary circulation, shortness of breath, dyspnea and cyanosis. In the fewer cases Isordil is recommended for the treatment of the inflammation of the inner lining of the arteries and other health conditions, which involve spasms of peripheral blood vessels.

In US and Europe Isordil is used for the treatment of such conditions as common and unstable angina, acute myocardial infarction including the cases with complications of acute left ventricular failure, conditions after myocardial infarction, spasms of the coronary arteries, pulmonary edema, hypertension in the "small" circle of blood, "pulmonary" heart and spasms of peripheral arteries. Among most common side effects are headaches, dizziness, nausea, which disappear if the dosage is decreased.

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