Lamictal is an anticonvulsant and antiepileptic medication. Lamictal works by inhibiting the release of glutamic acid, which plays a key role in causing epileptic seizures. This medication is used for the treatment of epilepsy (partial and generalized seizures, tonic-clonic seizures, seizures associated with Lennox-Gastaut syndrome, and bipolar disorders with predominantly depressive phases.

Active ingredient in Lamictal is Lamotrigine. Lamictal causes voltagedependent sodium channels of presynaptic membranes of neurons in a phase of slow inactivation. This process leads to a decrease in the allocation of neurotransmitters into the synaptic cleft, primarily glutamate (amino acids, which plays a key role in the development of an epileptic seizure).

After its administration Lamotrigine is rapidly and completely absorbed from the gastrointestinal tract. The maximum concentration in plasma is reached in about 2.5 h.

Lamictal is recommended for the treatment of epilepsy in children and adults. It is used as a monotherapy or supportive treatment of partial and generalized seizures, including tonic-clonic seizures and seizures associated with Lennox-Gastaut syndrome. Lamictal must not be administered by patients, having hypersensitivity to Lamotrigine as well as by those patients, who suffer from the severe liver damage or liver failure.

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