Macrobid is a medication with a wide spectrum of action; it is a derivative of nitrofuran and is referred to the group of drugs, called antimicrobials. Macrobid possesses a bacteriostatic and bactericidal function in infections of the urinary tract. Macrobid is active against Essherichia coli, Klebsiella spp., Enterobacter spp., Proteus spp.

Macrobid shows amazing results in the treatment of urinary tract infection. This medication is well absorbed in the gastrointestinal tract and the rate of absorption depends on the size of the crystals (microcrystalline form is characterized by rapid solubility and absorption rate, and consequently – with a short period of maximum concentration in the urine).

The presence of food in the gastrointestinal tract may increase the bioavailability. Therefore, for achieving better results it is worth to administer Macrobid during the meal. Macrobid crosses the placenta and the BBB and is excreted in breast milk. This drug is completely excreted by the kidneys 30-50% is excreted unchanged.

Macrobid is usually used for the treatment of such conditions as pyelitis, pyelonephritis, cystitis and urethritis. It is as well used as prophylaxis of the infection in urological surgery, cystoscopy and catheterization. Macrobid must be administered orally with the food, 3-4 times per day. The average dosage is 100-150 mg and a course of treatment lasts for 5-8 days. Macrobid must not be administered by patients who have hypersensitivity to any of the drug’s components, renal or liver failure and acute porphyria.

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