Motilium is an intestinal motility stimulant, which has an antiemetic effect. The active substance in Motilium is domperidone, which works as a dopamine antagonist. Compared to the metoclopramide and antipsychotic drugs, Motilium passes through the bad blood-brain barrier, so its acceptance is not accompanied by serious side effects. However, it is worth to know that domperidone enhances the release of pituitary prolactin cells.
The antiemetic effect is achieved by the combined action of antagonism of dopamine receptors located in the area of chemoreceptor trigger. Motilium increases the duration of antral and duodenal contractions and improves the gastric emptying. This medication performs no influence on the secretion of gastric juice.
Motilium is highly recommended for the treatment of such conditions as dyspepsia, delayed gastric emptying, sensation of bloating, vomiting, epigastric pain, bloating, belching, nausea, regurgitation and heartburn, infections of organic or functional nature, as well as nausea and vomiting associated with violation of the diet, radiotherapy or drug treatment. Motilium showed notable results in the treatment of cyclic vomiting syndrome, regurgitation, gastro-esophageal reflux and other changes in gastric motility in children.
This medication must not administered by people, suffering from perforation of the gastrointestinal tract, prolactinoma, gastrointestinal bleeding and hypersensitivity to domperidone or any other components of Motilium.
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