Pentosan polysulfate SP 54 is a medication that prevents the development of thrombosis and formation of lyses thrombi by increasing the endogenous fibrinolytic capacity, through the mechanism of fibrinolysis and AT Ill-independent effects of anticoagulants. Pentosan polysulfate SP 54 also improves the perfusion due to the reduction of blood viscosity by increasing the elasticity of red blood cells.

The active component of this medication releases the lipoprotein lipase, reducing in such a way the levels of total lipids, triglycerides and cholesterol in the blood. As a result, there can be observed the shift of lipoprotein fractions in the direction of high-density lipoprotein, which considerably decreases the risk of atherosclerosis.

Pentosan polysulfate SP 54 is recommended for the treatment of such conditions as acute, subacute and chronic atherosclerotic as well as thrombotic and thromboembolic diseases. It can also be applied as a prophylaxis of thrombotic and thromboembolic complications.

Pentosan polysulfate SP 54 must not be administered by persons, suffering from hemophilia, gastrointestinal bleeding of peptic ulcer, a recent hemorrhage in the brain, surgery on the brain or spinal cord and eye surgery, concomitant allergic (II type), thrombocytopenia, hemorrhage, the tendency towards the emergence of bleeding as in hemorrhagic diathesis. As a rule Pentosan polysulfate SP 1954 is well tolerated, yet in the rare cases there may appear allergic skin rashes, nausea and vomiting.

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