Plavix is an inhibitor of platelet aggregation, referred to the group of drugs called antiaggregatory drugs. Starting with the first day of administration Plavix significantly inhibits the platelet aggregation ad performs coronarydilative action, capable of preventing the development of atherothrombosis.

Plavix is widely used for prevention of ischemic disorders in patients with atherosclerosis: myocardial infarction, ischemic stroke, peripheral arterial thrombosis, including in acute coronary syndrome. The active substance in Plavix is clopidogrel. Clopidogrel selectively inhibits the binding of ADP (adenosine diphosphate) with platelet surface receptors. Due to this process occurs the ADP-induced activation of the complex GP IIb / IIIa, which leads to inhibition of platelet aggregation.

Plavix causes other reactions that contribute to the suppression of platelet aggregation. The effect of this medication on platelets is irreversible; therefore, throughout their period of existence these platelets will be unable to form aggregates. Restoration of aggregation properties of platelets occurs during the formation of new cells.

In US and Europe, Plavix is used for the treatment and preventions of atherothrombotic events in patients with ischemic stroke - is assigned to the interval from 7 days to 6 months after stroke. It as well has proven to be helpful in patients with peripheral arterial disease, myocardial infarction, acute coronary syndrome without elevation segment S-T. In patients suffering from this condition, Plavix is used in combination with acetylsalicylic acid (myocardial infarction in the absence of pathological Q wave on the electrocardiogram, unstable angina).

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