The growth of the prostate and subsequent development of adenoma, depend on the transformation of testosterone into a more active androgen - dihydrotestosterone in the prostate.

Proscar is a medication, referred to the group of drugs, called 5-alpha reductase inhibitors, antiandrogens. Proscar causes the decrease in the size of the prostate, improves urine flow and reduces symptoms associated with BPH. In Europe and US, Proscar is widely used in the treatment of benign prostatic hyperplasia to reduce the prostate size, improve the urine flow and reduce the risk of acute urinary retention.
Proscar inhibits the enzyme that transforms testosterone to dihydrotestosterone, and reduces the biosynthesis of dihydrotestosterone. After the administration of Proscar at a dose of 5 mg concentration of DHT in serum and in the prostate gland is effectively reduced in 24 hours. Suppression of formation of DHT is accompanied by a decrease in the size of the prostate gland, increase in the maximum speed of urine flow and decrease of the symptoms of urinary tract obstruction associated with BPH.

Proscar is most frequently indicated for the treatment of such condition as adenoma of the prostate for its ability to reduce the size of the prostate gland and symptoms associated with prostatic hyperplasia, improve urine flow and reduce the risk of acute urinary retention requiring catheterization or surgical intervention. It is worth to mention that Proscar is not effective in patients with prostate cancer.

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