Sinemet is a metabolic precursor for the treatment of Parkinson's disease syndrome. The active components of this medication are Carbidopa, MSD, an inhibitor of decarboxylase of aromatic amino acids and L-DOPA. Sinemet effectively provides long-lasting L-DOPA plasma levels at doses that are approximately 80% below the required doses in the case of mono treatment with L-DOPA.

This medication is perfect for the Parkinson's syndrome disease. It effectively reduces many symptoms of Parkinson's disease, especially bradykinesia. Besides the treatment of Parkinson's syndrome disease Sinemet is recommended for the treatment of tremor, dysphagia, and sialorei postural instability of the body associated with the disease and Parkinson's syndrome.

In case the response to mono treatment with L-DOPA is variable, and signs and symptoms of Parkinson's disease are not controlled during the whole day, the transfer to Sinemet usually results in reduced fluctuations. Sinemet provides an adequate reduction of symptoms of Parkinson's disease patients by reducing the certain adverse effects caused by L-DOPA.

Patients with hypersensitivity to any of the Sinemet components as well as those who suffer from angle-closure glaucoma must not administer this medication. Due to the fact that L-DOPA may stimulate the development of malignant melanoma, Sinemet should not be administered to patients with suspected non-diagnosed skin diseases or a history of melanoma.

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