Valtrex is an antiviral medication, the analog of nucleoside. After the administration of Valtrex, it is absorbed and almost completely converted to acyclovir under the influence of hepatic enzyme valaciclovir-hydrolase. Acyclovir, which derives from valaciclovir, the main component of Valtrex, penetrates the cell affected by the virus, where under the influence of the viral enzyme thymidinekinase turns into a monophosphate, then, influenced by cellular kinases - in the active diphosphate and triphosphate.
Acyclovir triphosphate inhibits the DNA polymerase and, thus, violates the replication of virus DNA. Thus, the high selectivity of Valtrex for tissues infected with a virus, can be explained by the fact that the stage I reaction chain - phosphorylation is mediated by the enzyme produced by the virus itself.
Valtrex is recommended for the treatment of such conditions as Herpes simplex virus types 1 and 2, Varicella zoster, cytomegalovirus, Epstein-Barr virus, shingles, infections of the skin and mucous membranes caused by the herpes simplex virus. Valtrex is as well used for prevention of recurrence of herpes simplex and cytomegalovirus infection on the background of immunodeficiency.
Valtrex is administered orally with or without food. This medication must not be taken by patients who have hypersensitivity to any of Valtrex components, as well as by children under the age of 12 years old. Valtrex must be used with caution in pregnant or breastfeeding women. Although this medication is usually well tolerated, in rare cases patients may feel headache.
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