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What is Roaccutane?
Roaccutane is a very effective medicine used in severe acne therapy. The medicine is used in the severest cases resistant to other types of treatment.

What is the action mechanism of Roaccutane?
The active ingredient of Roaccutane is Isotretinoin which, influencing on the inner microflora, violates the expression of the gene responsible for the synthesis of certain proteins and inhibits the production of sebaceous glands as well as reduces their size showing anti-inflammatory action.

What is the proper dosage of Roaccutane?
The proper dosage of Roaccutane should be determined by doctor ONLY because the therapeutic response to this medicine may vary depending on the patient’s condition and tolerance to Roaccutane as well as Generic Roaccutane. The usual initial dose is 0.5 mg / kg body weight per day. In most patients the dose can range from 0.5 mg / kg to 1.0 mg / kg per day. The medicine should be taken orally during your meal one or two times per day. After about 4 weeks of treatment the dose can be altered depending on the clinical effect intensity. Typically the course of treatment lasts for 16 weeks.

What are the possible adverse effects of Roaccutane?
Most Roaccutane adverse reactions are dose dependent. As a rule the side effects are reversible, but some of them may persist. The drug has a strong teratogenic action. Among Roaccutane side effects there are:
- hypervitaminosis A associated symptoms: skin and mucosa dryness (dryness of lips, mouth, nose, throat, eyes), mucocutaneous;
- sweating, itching, rashes, skin eruptions, redness, inflammation;
- muscle and joint pains, arthritis, tendons and ligaments calcifications, reduced bone density, back pain, tendinitis, other bone changes;
- depression, headaches, suicide attempts;
- photophobia, conjunctivitis, lenticular cataracts;
- some cases of hepatitis;
- neutropenia, anemia, thrombocytopenia;
- systemic or local infections caused by gram-positive microbes;
For more information on Roaccutane side effects please refer to the Patient Information Leaflet.

Inform your doctor immediately if having any of the following:
- stomach pain or severe stomach pain, nausea, vomiting, diarrhea;
- seizure or severe headache;
- disturbance of vision;
- blood in urine;
- breathing difficulties.
Also please inform your doctor on the subject of any changes in your condition you think might be caused by Roaccutane.

Are there any contraindications?
One should not take Roaccutane if allergic to Isotretinoin or other drug components. It should be carefully taken if having depression in past history, pancreatic diabetes, obesity, alcoholism, dyslipidemia, hypervitaminosis A, liver impairment. Pregnancy is an absolute contraindication to Roaccutane therapy. If despite all the precautions pregnancy occurs during the treatment or within one month after it has been ended there is a great danger of having a baby with severe development disabilities! Also breastfeeding women cannot take this medicine.
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